It is likely that the adverse effect profile of Invega will be similar to that of risperidone The results of two recent publicly funded studies designed to evaluate the effectiveness of these treatments under real-world conditions have called into question these prescribing preferences.The Clinical Anti-psychotic Trials of Intervention Effectiveness study was designed to compare the FGA perphenazine with several SGAs, using “all-cause discontinuation” as a proxy measure for effectiveness.4 The Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study measured quality of life and other effectiveness measures.5 Neither study demonstrated a clear difference in effectiveness between FGAs and non-clozapine SGAs.For information about the SORT evidence rating system, go to https://org/A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series.
Because aripiprazole decreases alcohol’s euphoric effects and increases its sedative effects, this drug could be useful in the treatment of heavy drinking, Kranzler’s team concludes.
Overall, the findings suggest that “additional research on the effects of aripiprazole on the subjective effects of alcohol is warranted.” SOURCE: Alcoholism: Clinical & Experimental Research, March 2008.
During the session, the participants consumed alcohol served as three standardized drinks, individually measured according to their sex, body height and body weight.
The authors measured breath alcohol concentration, heart rate, blood pressure, equilibrium, and subjective effects of alcohol regularly throughout the sessions.
They reported drinking moderately in the 90 days prior to study enrollment: an average of 19.5 days of drinking, 1.8 days of heavy drinking, for a total of 47.8 standard drinks consumed.
The subjects were assigned to take part in three experimental sessions in random sequence: no medication; 2.5 milligrams of aripiprazole; or 10 milligrams of aripiprazole on the day prior to the laboratory session.
They should be vigilant for the occurrence of adverse effects, be willing to adjust or change medications as needed (or work with psychiatric colleagues to do so), and be prepared to treat any resulting medical sequelae.
A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series.
The consumption of alcohol led to the expected physiological and subjective responses.